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This is a study of the glycerol synthesis pathway, using model predictions and experimental measurements
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Created: 19th Aug 2011 at 09:35
Last updated: 4th Nov 2011 at 10:06

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Expertise: Biochemistry, Bioinformatics, Data Management
Tools: Data Management, Transcriptomics, Databases, Workflows, Web services, Taverna, Ontologies
I am a Research Fellow at the University of Manchester, working in Bioinformatics and Computer Science. I am also a guest researcher at the Vrije Universiteit.My research interests include scientific workflows, semantic discovery, and applying ontology technologies to biological data
The main objectives of SysMO-DB are to: facilitate the web-based exchange of data between research groups within- and inter- consortia, and to provide an integrated platform for the dissemination of the results of the SysMO projects to the scientific community. We aim to devise a progressive and scalable solution to the data management needs of the SysMO initiative, that:
* facilitates and maximises the potential for data exchange between SysMO research groups;
* maximises the ‘shelf life’ and
...
Programme: SysMO
Public web page: http://www.sysmo-db.org/
Organisms: Saccharomyces cerevisiae, Lactic Acid Bacteria
Glycerol, a major by-product of ethanol fermentation by Saccharomyces cerevisiae, is of significant importance to the wine, beer, and ethanol production industries. This investigation aims to gain a clearer understanding of and to quantify the extent to which parameters of the pathway affect glycerol flux in S. cerevisiae.
This investigation represents the data and models submitted to JWS online by Cronwright et al
(http://jjj.biochem.sun.ac.za/cgi-bin/getMoreInfo.py?modeldir=cronwright) and
...
Snapshots: No snapshots
Scales: Not specified
A kinetic model of the glycerol synthesis pathway has been constructed. Kinetic parameters were collected from published values. Maximal enzyme activities and intracellular effector concentrations were determined experimentally.
Investigation: Glycerol Synthesis in Saccharomyces cerevisiae
Study: Glycerol Synthesis Pathway
Organisms: Saccharomyces cerevisiae
Models: Metabolic Control Analysis of Glycerol Synthesi...
SOPs: No SOPs
Data files: Cronwright Parameter Data
Scales: Not specified
An assay to measure exttracellular glycerol using HPLC
Submitter: Katy Wolstencroft
Assay type: Metabolite Profiling
Technology type: HPLC
Snapshots: No snapshots
Investigation: Glycerol Synthesis in Saccharomyces cerevisiae
Study: Glycerol Synthesis Pathway
Organisms: Saccharomyces cerevisiae
SOPs: No SOPs
Data files: 1 hidden item
Scales: Not specified
Intracellular metabolite concentrations were determined enzymatically by measuring the oxidation or reduction of NADH or NAD+, respectively, at 340 nm in a Beckman Coulter DU640 spectrophotometer
Submitter: Katy Wolstencroft
Assay type: Intracellular Metabolite Concentration
Technology type: Enzymatic Activity Measurements
Snapshots: No snapshots
Investigation: Glycerol Synthesis in Saccharomyces cerevisiae
Study: Glycerol Synthesis Pathway
Organisms: Saccharomyces cerevisiae
SOPs: No SOPs
Data files: Cronwright Parameter Data
Scales: Not specified
Intracellular metabolite measurements used for validation of the gycerol synthesis pathway model
Creator: Jacky Snoep
Submitter: Katy Wolstencroft
Investigations: Glycerol Synthesis in Saccharomyces cerevisiae
Studies: Glycerol Synthesis Pathway
Assays: Glycerol Synthesis Model construction, Intracellular Metabolites
Scales: Not specified
MCA of Glycerol Synthesis in Saccharomyces cerevisiae
Creators: Jacky Snoep, Garth R. Cronwright, Johann M. Rohwer, and Bernard A. Prior
Submitter: Katy Wolstencroft
Model type: Ordinary differential equations (ODE)
Model format: SBML
Environment: Not specified
Organism: Saccharomyces cerevisiae
Investigations: Glycerol Synthesis in Saccharomyces cerevisiae
Studies: Glycerol Synthesis Pathway
Modelling analyses: Glycerol Synthesis Model construction
Scales: Not specified
Abstract (Expand)
Authors: Garth R Cronwright, Johann M Rohwer, Bernard A Prior
Date Published: 30th Aug 2002
Publication Type: Not specified
PubMed ID: 12200299
Citation:
Scales: Not specified