Mathematical model for the combined four enzyme system Version 7
Simulate Model on JWSThe PGK, GAPDH, TPI and FBPAase were modelled together using the individual rate equations. Closed system.
SEEK ID: https://demo.fairdomhub.org/models/29?version=7
6 items (and an image) are associated with this Model:-
ssolfGluconeogenesisOpenAnn.dat (uuencoded file - 3.43 KB)
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ssolfGluconeogenesisOpenAnn.xml (XML document - 20.2 KB)
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ssolfGluconeogenesisOpenAnn.xml (XML document - 20.2 KB)
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ssolfGluconeogenesisAnn.xml (XML document - 20.3 KB)
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ssolfGluconeogenesisClosed.xml (XML document - 18.9 KB)
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ssolfGluconeogenesis.xml (XML document - 18.9 KB)
Organism: Sulfolobus solfataricus
Model type: Ordinary differential equations (ODE)
Model format: SBML
Execution or visualisation environment: JWS Online
Model image: (Click on the image to zoom) (Original)
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Creators and Submitter
Views: 8643 Downloads: 1237
Created: 6th Feb 2013 at 10:07
Last updated: 28th May 2015 at 08:50
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Version History
Version 7 (latest) Created 6th Feb 2013 at 10:07 by Jacky Snoep
Four enzyme open system reactions and species annotated .dat file
Related items
SysMO is a European transnational funding and research initiative on "Systems Biology of Microorganisms".
The goal pursued by SysMO is to record and describe the dynamic molecular processes going on in unicellular microorganisms in a comprehensive way and to present these processes in the form of computerized mathematical models.
Systems biology will raise biomedical and biotechnological research to a new quality level and contribute markedly to progress in understanding. Pooling European research ...
Projects: BaCell-SysMO, COSMIC, SUMO, KOSMOBAC, SysMO-LAB, PSYSMO, SCaRAB, MOSES, TRANSLUCENT, STREAM, SulfoSys, SysMO DB
Web page: http://sysmo.net/
Silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation
Programme: SysMO
Public web page: http://sulfosys.com/
An investigation in the CCM of S. solfataricus with a focus on the unique temperature adaptations and regulation; using a combined modelling and experimental approach.
Submitter: Jacky Snoep
Studies: Carbon loss at high T, Model gluconeogenesis, Pathway optimisation
Assays: Experimental assays of the temperature dependent degradation of GAP and ..., FBPA/ase, FBPAase model, GAPDH, GAPDH modeling, Gluconeogenic model, Model reconstituted system, Modelling pathway optimisation, Modelling temperature dependent degradation of GAP and DHAP, PGK, PGK and FBPAase titrations, PGK modeling, Reconstituted system reference state, TPI, TPI modeling
Submitter: Jacky Snoep
Investigation: Central Carbon Metabolism of Sulfolobus solfata...
Assays: Model reconstituted system, Reconstituted system reference state
Mathematical model of a subset of reactions comprising the three most temperature sensitive intermediates of the gluconeogenic pathway in S. solfataricus
Submitter: Jacky Snoep
Investigation: Central Carbon Metabolism of Sulfolobus solfata...
Assays: Experimental assays of the temperature dependent degradation of GAP and ..., FBPA/ase, FBPAase model, GAPDH, GAPDH modeling, Gluconeogenic model, Modelling temperature dependent degradation of GAP and DHAP, PGK, PGK modeling, TPI, TPI modeling
By varying the input or output flux via PGK and FBPAase manipulation respectively the pathway efficiency can be optimised.
Submitter: Jacky Snoep
Investigation: Central Carbon Metabolism of Sulfolobus solfata...
Assays: Modelling pathway optimisation, PGK and FBPAase titrations
Mathematical model for the analysis of carbon loss of BPG, GAP and DHAP in reconstituted system of S. solfataricus at 70C.
Submitter: Jacky Snoep
Biological problem addressed: Model Analysis Type
Investigation: Central Carbon Metabolism of Sulfolobus solfata...
Study: Model gluconeogenesis
Mathematical model for the reconstituted system with PGK, GAPDH, TPI and FBPAase.
Submitter: Jacky Snoep
Biological problem addressed: Model Analysis Type
Investigation: Central Carbon Metabolism of Sulfolobus solfata...
Study: Carbon loss at high T
Varying the relative amounts of PGK and FBPAase and analyse the 3PG uptake and F6P production rates.
Submitter: Jacky Snoep
Biological problem addressed: Model Analysis Type
Investigation: Central Carbon Metabolism of Sulfolobus solfata...
Study: Pathway optimisation
Abstract (Expand)
Authors: T. Kouril, D. Esser, J. Kort, H. V. Westerhoff, B. Siebers, J. L. Snoep
Date Published: 22nd Aug 2013
Publication Type: Not specified
