Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry
This study examines whether the in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes.
Projects: SysMO DB
Experimentalists: Not specified
Created: 5th Jul 2010 at 16:27
Last updated: 4th Nov 2011 at 11:06
I am a Research Fellow at the University of Manchester, working in Bioinformatics and Computer Science. I am also a guest researcher at the Vrije Universiteit.My research interests include scientific workflows, semantic discovery, and applying ontology technologies to biological data
The main objectives of SysMO-DB are to: facilitate the web-based exchange of data between research groups within- and inter- consortia, and to provide an integrated platform for the dissemination of the results of the SysMO projects to the scientific community. We aim to devise a progressive and scalable solution to the data management needs of the SysMO initiative, that:
* facilitates and maximises the potential for data exchange between SysMO research groups;
* maximises the ‘shelf life’ and
Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried out on cell-growth regulation. Comprehensive studies at the transcriptional, proteomic and metabolic levels under defined controlled conditions are currently lacking.
This investigation shows public data taken from the BioInvestigation Index. (http://www.ebi.ac.uk/bioinvindex/study.seam?studyId=BII-S-1)
Organism: Saccharomyces Cerevisiae
Snapshots: Snapshot 1
Scales: Not specified
Glycolysis in Saccharomyces cerevisiae
Investigation: Growth control of the eukaryote cell: a systems...
Organisms: Saccharomyces cerevisiae (chemostat)
Models: Teusink and 1 hidden item
SOPs: No SOPs
Data files: No Data files
Scales: Not specified
This model is for a paper that examines whether the in vivo behavior of yeast glycolysis can be understood in terms of the in vitro kinetic properties of the constituent enzymes. In non-growing, anaerobic, compressed Saccharomyces cerevisiae the values of the kinetic parameters of most glycolytic enzymes were determined. For the other enzymes appropriate literature values were collected. By inserting these values into a kinetic model for glycolysis, fluxes and metabolites were calculated. Under
Creator: Stuart Owen
Contributor: Stuart Owen
Model type: Not specified
Model format: SBML
Environment: Not specified
Organism: Saccharomyces cerevisiae
Investigations: Growth control of the eukaryote cell: a systems...
Modelling analyses: Glycolysis in Saccharomyces cerevisiae